capsules 100мг, capsules 150мг, capsules 200мг

Bristol-Myers Skvibb (the United States of America)

Protivovirusnye-anti-ViCh means

Atazanavir

Atazanavir.

Renders protivovirusnoe-anti-ViCh dejstvie. Primenenie atazavira together with food improves its bioavailability and reduces farmakokineticheskuju variabelnost. Stepen linkages with fibers does not depend on concentration. It is defined in spinno-brain and seed zhidkosti.

Treatment of a HIV-1 of infections in a combination with others antiretrovirusnymi preparations, for patients, before receiving antiretrovirusnuju therapy and earlier nelechennyh patients.

Hypersensitivity to atazanaviru or to any auxiliary substance which is a part of a preparation, heavy hepatic insufficiency (for a combination with ritonavirom); hereditary metabolic infringements (intolerance galaktozy, deficiency of lactose and infringement vsasyvanija glucose and galaktozy); age to 18 let. Primenenie at pregnancy it is possible, if the expected effect of therapy exceeds potential risk for a fruit. For the period of treatment it is necessary to stop chest feeding.

From immune system: allergic reaktsii. So parties TSNS: Headaches, sleeplessness, peripheral neurologic symptoms, trouble, depression, the infringements of a dream disturbing dreams, memory loss, confusion of consciousness, sonlivost. So parties ZHKT: pains in a belly cavity, a diarrhoeia, dispepsija, a nausea, vomiting, a taste distortion, meteorizm, a gastritis, a pancreatitis, aftoznyj a stomatitis, dryness in rtu. So the parties of integuments and skin appendages: a rash, oblysenie, an itch, krapivnitsa, vazodilatatsija, vezikulobulleznaja syp. Rasstrojstva the oporno-impellent device and infringement of connecting fabrics: artralgija; a muscular atrophy, mialgija, miopatiya. With the parties mochevydelitelnoj systems: gematurija, speeded up mocheispuskanie, proteinurija, pains in kidneys, pochechno-stone bolezn. Rasstrojstva sight bodies: ikterichnost Ledershдute. Violations a metabolism: lipodistrofija, an anorexia, the raised appetite, decrease in weight of a body, weight addition tela. So the parties of reproductive system: ginekomastiya. Gepatobiliarnye Frustration: a jaundice, a hepatitis, gepatosplenomegaliya. Disorders the general character: the general weakness, pains in breasts, weariness, a fever, the general nedomoganie. Izmenenie laboratory indicators: Increase of the general bilirubin, and with prevalence of increase of indirect (untied) bilirubin, level increase amilazy, kreatinkinazy, AlT/syvorotochnoj glutaminovoj pirovinogradnoj transaminazy, low level nejtrofilnyh the leukocytes, raised maintenance AsT/syvorotochnoj glutaminovoj shchavelevouksusnoj transaminazy, level increase lipazy.

Joint application atazanavira and other preparations, metabolizirujushchihsja CYP3A4 can lead to increase in plasma of concentration of one of them that promotes increase or its prolongation therapeutic and collateral effektov. Sovmestnoe application atazanavira and the preparations inducing CYP3A4 can lead to concentration decrease atazanavira in plasma and to decrease in its therapeutic effect. Joint application of a preparation and preparations, ingibirujushchih CYP3A4, can lead to concentration increase atazanavira in plazme. Preparat does not influence efficiency didanozina, therefore preparations didanozina should be accepted through 2 ch after reception atazanavira. At simultaneous application tenofovir reduces action atazanavira. At simultaneous application efavirenz reduces action atazanavira. From absence of data joint application with a combination of a preparation and ritonavira not recommended. Indinavir is capable to call giperbilirubinemiju (increase of concentration of indirect bilirubin) by inhibition UGT. Therefore simultaneous application with atazanavirom not recommended. At simultaneous application with atazanavirom effect sakvinavira decreases. Ritonavir. At joint application with atazanavirom concentration atazanavira uvelichivaetsja. Odnovremennoe application of a combination of a preparation with ritonavirom with others IP not recommended. Amiodaron, lidocaine (system introduction), hinidin: at simultaneous reception with a preparation probably increase in their concentration. Reception in such combinations demands the raised care, it is recommended to watch therapeutic concentration of these preparations. Hinidin it is counter-indicative at joint application of a preparation with ritonavirom. Not simultaneous application with simvastatinom and lovastatinom. Recommended dose decrease diltiazema on 50 % is recommended and the control for EKG. Bepridil is counter-indicative at preparation application in a combination with ritonavirom. Inhibitirs GMG - Koa - reduktazy (simvastatin, lovastatin, atorvastatin, tserivastatin): at joint application with a preparation action atorvastatina and tserivastatina can increase. Blokatory H2-receptors and ingibitory a proton pomp reduce concentration atazanavira in blood whey that can lead to decrease in therapeutic activity of a preparation or to development rezistentosti. To accept these preparations follows separately. Immunodepressants (tsiklosporin, takrolimus, sirolimus): at joint application tsiklosporina, takrolimusa, sirolimusa and a preparation probably increase in concentration blood immunodepressants. At joint application klaritromitsina with atazanavirom, the antibiotic dose should be lowered on 50 %. Peroral contraceptives it is not recommended to accept simultaneously with a preparation. It is expedient to use other reliable methods kontratseptsii. Aktivnost rifabutina at joint application with atazanavirom increases. Rifampitsin reduces activity of majority IP approximately on 90 %. Simultaneously to apply with atazanavirom not follows. At joint application ingibitorov proteazy with ingibitorami fosfodiesterazy the increase in concentration of the last and their strengthening collateral effektov. Sleduet is possible to be careful at purpose ketokonazola and itrakonazola in a daily dose above 200 mg together with a combination of preparations atazanavir and ritonavir. Varfarin: simultaneous application with atazanavirom can call a bleeding essential and-or menacing to a life because of activity strengthening varfarina. Bolee the detailed information see the instruction on primeneniju.

Symptoms: a jaundice owing to increase of level of indirect bilirubin (without other signs of infringement of function of a liver) and infringement of a warm rhythm (lengthening of interval PR). Treatment: Monitoring procedure of the basic physiological indicators and electrocardiogram, stomach washing, provocation of vomiting for removal of the preparation not soaked up in blood, purpose of the activated coal, patsienta. Dializ neeffektiven. Spetsifichesky an antipillbox otsutstvuet.

the Decision on the therapy beginning accepts supervision over the general status the doctor having experience of treatment Vich-infekciy. On a background of treatment ingibitorami proteazy at some HIV-infected of patients are noted giperglikemija, occurrence of a diabetes or dekompensatsija an available diabetes. In some cases it was marked diabetic ketoacidoz. An patients with a hemophilia of type And and In against treatment IP are described bleedings Patients with a hemophilia should are warned about possibility such oslozhnenij. Patsientov it is necessary to warn that antiretrovirusnaja therapy does not prevent risk of transfer of a HIV through blood or during sexual contacts in this connection it is necessary to observe measures predostorozhnosti. Snizhenie doses azanavira it is not recommended, since long-term efficiency of the lowered doses was not ustanovlena. Syp usually from easy to average degree makulopapuleznyh vysypany is observed within the first 3 weeks from the therapy beginning atazanavirom. At the majority of patients the rash disappears within 2 weeks at therapy continuation. Primene nie atazanavira should be stopped at development heavy sypi. Bolee the detailed information the Encyclopedia of Medicines 2006г see the instruction on primeneniju.

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